›› 2012, Vol. 24 ›› Issue (2): 129-131.doi: 10.3969/j.issn.1004-616x.2012.02.011

• 论著 • 上一篇    下一篇

IQGAP1在哈萨克族食管癌组织中的表达及意义

古丽努尔·木哈依,李 卉,李秀梅,陈 艳,姜孝芳,马丽丽,李惠武,谌宏鸣   

  1. 新疆医科大学基础医学院,新疆 乌鲁木齐 830011
  • 收稿日期:2011-11-17 修回日期:2011-12-25 出版日期:2012-03-30 发布日期:2012-03-30
  • 通讯作者: 谌宏鸣

The expression and clinical significance of IQGAP1 in esophageal cancer of Kazaks

  • Received:2011-11-17 Revised:2011-12-25 Online:2012-03-30 Published:2012-03-30
  • Contact: CHEN Hong-ming

摘要: 目的: 检测IQ结构域三磷酸鸟苷合酶-激活蛋白1 (IQ domain GTPase-activating protein 1, IQGAP1)在哈萨克族食管癌组织中的表达,分析其与临床病理参数的相关性。方法:采用逆转录PCR (reverse transcription polymerase chain reaction,RT-PCR)检测48例哈萨克族食管癌切除标本中癌组织与远端无癌组织中IQGAP1 mRNA表达水平,并分析其与临床病理指标的关系。结果:癌组织中IQGAP1 mRNA表达阳性率 (50%)高于其远端无癌组织 (21%),其差异具有统计学意义 (P < 0.05);但IQGAP1 mRNA的表达与癌组织分化程度、病理分期及有无淋巴结转移均无相关性 (P > 0.05)。 结论:IQGAP1基因的表达可能与哈萨克族食管癌的发生有关。

关键词: 哈萨克族, 食管肿瘤, IQGAP1

Abstract: OBJECTIVE: To investigate the expression of IQGAP1 in esophageal cancer tissues and its relationship between their expressions and the clinical pathological features in Kazaks. METHODS:The mRNA expression level of IQGAP1 in 48 Kazak's esophageal cancer specimens were measured by RT-PCR. The relationship between clinical pathologic features and expressions of IQGAP1mRNA level was analyzed. RESULTS:The expression of IQGAP1 mRNA in cancer tissues was (50%) significantly higher than that of normal tissues (P<0.05). However,the expression level of IQGAP1 mRNA was not significantly related to the degree of differentiation,depth of invasion and lymph node metastasis. CONCLUSION:IQGAP1 gene expression may be related to the development of esophageal cancer with Kazak.

Key words: Kazak, esophageal neoplasms, IQ domain GTPase-activating protein 1